Building-Bridge Integrated System BBIS is one of the commonly used structure types in High-Speed Railway station ,and it has a complex structure and unclear seismic performance. Moreover, BBIS structure is still short of experiments to verify. Based on the typical structure of Tianjin West Railway Station example, carries on the scale ratio of 1/35 of the shaking table model test was conducted and research on the multi-stage bidirectional typical seismic behavior under seismic excitation was performed. Through comparing the results of experiment analysis with the finite element calculation, obtain the dynamic response characteristics and damage district of the structure under different level bidirectional earthquake was obtained. Meanwhile, the study points out that the seismic performance of current design station structure is good but conservative, the weak position is mainly concentrated in the upper roof structure.