In this work, the influences of corrosion on fatigue life of prestressing strand were studied. First, a multi-parameter Weibull model for fatigue life evaluation was established based on the current three-parameter Weibull model, which considers the influences of the corrosion degree on the slope of the SN curve and the characteristic fatigue life within a specified stress range for prestressing strands. The corrosion degree and stress range were regarded as the co-variables for the proposed Weibull model. Also, the proposed model can provide the quantitative influences of corrosion on fatigue life of corroded prestressing strands. As a matter of fact, to ensure the physical meaning of the proposed fatigue model, several conditions shall be satisfied for the parameters of the proposed model. The maximum likelihood estimation was employed to estimate the parameters considering all the fatigue data with different corrosion degrees and stress ranges. The spatial surfaces of fatigue life, stress range, and corrosion degree with different survival probabilities were established based on the fatigue data of corroded prestressing strands provided in literature. The results indicate that the proposed Weibull model can be used to evaluate the fatigue life of corroded prestressing strand, which reflects quantitative influences of corrosion degree on fatigue life of prestressing strand. In particular, the results indicate that the fatigue life of prestressing strand is sensitive to corrosion. Fatigue life decreases sharply as corrosion degree increases for corroded prestressing strand. Moreover, the effect is more pronounced for lower stress ranges. The allowable stress range decreases sharply for a specified fatigue life of prestressing strand as the corrosion degree increases. Therefore, to prevent premature fatigue induced failures, avoiding corrosion of prestressing strand during the structural service period is crucial. In brief, the Weibull model proposed in this study can be used to evaluate the fatigue performance of prestressed concrete structures in service.