To solve the key technical problems of seismic design of industrial buildings, the dynamic multi-objective seismic fortification theory and the corresponding quantitative performance index system with bearing capacity, stiffness and ductility matching each other are established. The seismic design method with hierarchy of system and echelon of component is put forward, and the corresponding quantitative control criterion is given, which solves the technical problem of continuous collapse prevention of industrial buildings in earthquake. Based on the logical relationship between the structural energy dissipation capacity and energy consumption demand, the concept of seismic redundancy demand ratio is proposed, and the corresponding quantitative classification evaluation standard is given. The seismic optimization design method based on the principle of equal energy is put forward, which straightens the logical matching relation of stiffness, strength and ductility in the seismic design of steel structure, and makes up some shortcomings of the current standard. A simplified design method considering the equipment-structure coupling effect is put forward, and the corresponding boundary index is given. According to the existing research results of seismic hazard, a method for determining the adjustment coefficient for the recurrence period of the peak seismic ground motion acceleration is established. A series of technologies, such as the TMD damping system with adjustable quality, special functional material, and in-service prestressing reinforcement technology, have been developed, which effectively solvethe problem of improving the seismic performance under continuous production conditions.