In order to study crosswind response and aerodynamic damping ratio of super high-rise buildings with hexagonal section, a series of wind tunnel tests for multiple degrees-of-freedom (MDOF) aeroelastic models were carried out. The wind-induced displacement and acceleration response at the top of the models were measured, and the crosswind aerodynamic damping ratio was identified by the random decrement technique. The results reveal that vortex induced vibration (VIV) phenomenon may easily appear when the wind attacks one corner of the hexagonal building, while there is no VIV phenomenon when the wind attacks one facade of the hexagonal building. When the wind attacks one corner, crosswind aerodynamic damping ratio may experience a complete process of firstly increasing to the maximum positive value, and then quickly decreasing to the minimum negative value, and next increasing slowly to the vicinity of zero with the increase of reduced wind speed. When the wind attacks one fa?ade, a linear relationship between the crosswind aerodynamic damping ratio and the reduced wind speed can be observed. Finally, the formula of crosswind aerodynamic damping ratio is established. This study can provide references for wind resistant design and standard improvement of super high-rise building with hexagonal section.